Fibrous and Globular Proteins Multiple Choice Questions(MCQs) & Answers

(1) What is the shape of the oxygen dissociation curve of myoglobin?

[A] Linear

[B] Hyperbola

[C] Sigmoid

[D] Parabola

Answer: Hyperbola

(2) In which iron(Fe) state myoglobin binds to the oxygen?

[A] Fe2+

[B] Fe3+

[C] Fe

[D] Fe4+

Answer: Fe2+

(3) What is the name of protein which is found in nail, hair, and horns?

[A] Myoglobin

[B] Hemoglobin

[C] Keratin

[D] Collagen

Answer: Keratin

(4) What is the function of myoglobin?

[A] Oxygen storage

[B] Oxygen carrier

[C] Antioxidant

[D] Oxidant

Answer: Oxygen storage

(5) Which of these type of curve shows the oxygen binding capacity of hemoglobin?

[A] Hyperbolic curve

[B] Sigmoidal curve

[C] Exponential curve

[D] Linear curve

Answer: Sigmoidal curve

(6) Name the protein which is responsible for extensibility and elasticity of connective tissues.

[A] Collagen

[B] Elastin

[C] Actin

[D] Keratin

Answer: Elastin

(7) Arrange the following sequence of collagen synthesis in the correct order.

1) The entrance of polypeptide into the rough endoplasmic reticulum

2) Packaged in to transport vesicle

3) Hydroxylation of lysyl and prolyl residues

4) Formation of tropocollagen

5) Covalent cross-linking of tropocollagen

6) Collection of fibrils

[A] 2, 3, 4, 1, 6, 5

[B] 4, 3, 2, 1, 5, 6

[C] 1, 2, 3, 4, 6, 5

[D] 1, 3, 4, 2, 5, 6

Answer: 1, 3, 4, 2, 5, 6

(8) Name the vitamins which cause scurvy.

[A] Vitamin B

[B] Vitamin B3

[C] Vitamin C

[D] Vitamin K

Answer: Vitamin C

(9) What is the fundamental unit of collagen?

[A] Tropocollagen

[B] Hydroxyproline

[C] Hydroxylysine

[D] Glycine

Answer: Tropocollagen

(10) Which of these are the possible cause of sickle cell anemia with respect to hemoglobin:

[A] Defect in β-chain of hemoglobin

[B] Defect in α-chain of hemoglobin

[C] One copy of an abnormal β-globin gene

[D] Two copies of an abnormal β-globin gene

Answer: Two copies of an abnormal β-globin gene

(11) Which of the following statements is false?

[A] Primary structure of a protein determines how it folds up into a unique three dimensional structure

[B] Secondary structure of a protein determines how it folds up into a unique three dimensional structure

[C] Three dimensional structure of a protein determines the function of a protein

[D] Amino acid sequence is absolutely invariant for a particular protein

Answer: Secondary structure of a protein determines how it folds up into a unique three dimensional structure

(12) Who deduced the double-helical structure of DNA?

[A] Frederick Sanger

[B] Mendel

[C] Watson and Francis Crick

[D] Anton van Leeuwenhoek

Answer: Watson and Francis Crick

(13) Two chains of amino acids in an insulin molecule are held together by

[A] Sulfide bridges

[B] Disulfide bridges

[C] Peptide bond

[D] Covalent linkage

Answer: Disulfide bridges

(14) Tertiary conformation of proteins is maintained by 3 types of bonds namely ionic, hydrogen and

[A] Sulfide

[B] Disulfide

[C] Covalent

[D] Peptide

Answer: Disulfide

(15) Hemoglobin is a

[A] Monomer

[B] Dimer

[C] Trimer

[D] Tetramer

Answer: Trimer

(16) Which of the following is false?

[A] The two main types of secondary structure are the α helix and β pleet structures

[B] α helix is a right handed coiled strand

[C] The hydrogen bonding in a β-sheet is between strands rather than within strands

[D] The hydrogen bonding in a β-sheet is within strands rather than between strands

Answer: The hydrogen bonding in a β-sheet is within strands rather than between strands

(17) Native state of a protein can be disrupted by

[A] Temperature

[B] pH

[C] Removal of water

[D] Presence of hydrophilic surfaces

Answer: Presence of hydrophilic surfaces

(18) Which of the following is true?

[A] The disulfide bridges formed by reduction of the sulfhydryl groups on cysteine stabilizes protein tertiary structure

[B] The disulfide bridges formed by oxidation of the sulfhydryl groups on cysteine destabilizes protein tertiary structure

[C] The disulfide bridges formed by oxidation of the sulfhydryl groups on cysteine stabilizes protein tertiary structure

[D] The disulfide bridges formed by reduction of the sulfhydryl groups on cysteine destabilizes protein tertiary structure

Answer: The disulfide bridges formed by oxidation of the sulfhydryl groups on cysteine stabilizes protein tertiary structure

(19) Identify the wrong statement

[A] Hemoglobin is a globular protein

[B] Hemoglobin is a fibrous protein

[C] Fibrous proteins are insoluble in water

[D] Collagen is a fibrous protein

Answer: Hemoglobin is a fibrous protein

(20) In 3° structure of proteins, folding and shaping is done by

[A] Hydrophobic interactions

[B] Polar interactions

[C] Hydrogen bonding

[D] None of the mentioned

Answer: Hydrophobic interactions

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