Hypersecretion of growth hormone in adults does not cause further increase in height, because

Hypersecretion of growth hormone in adults does not cause further increase in height, because

Option 1 : Bones lose their sensitivity to growth hormone in adults.
Option 2 : Epiphyseal plates close after adolescence.
Option 3 : Growth hormone becomes inactive in adults.
Option 4 : Muscle fibres do not grow in size after birth.

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