Home ยป In Sickle cell anaemia, the defect lies in which polypeptide Cell Organelles In Sickle cell anaemia, the defect lies in which polypeptide January 19, 2022 7 Views Q. In Sickle cell anaemia, the defect lies in which polypeptide A. Alpha chain B. Beta chain C. Gamma chain D. All of the above Answer: Beta chain