Home ยป In Sickle cell anaemia, the defect lies in which polypeptide Cell Organelles In Sickle cell anaemia, the defect lies in which polypeptide January 19, 2022 11 Views Q. In Sickle cell anaemia, the defect lies in which polypeptide A. Alpha chain B. Beta chain C. Gamma chain D. All of the above Answer: Beta chain