India reports unique ‘double mutant’ coronavirus variant

A unique “double mutant” coronavirus variant with a combination of mutations not seen anywhere else in the world has been found in India.

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However, it is still to be established if this has any role to play in increased infectivity or in making COVID-19 more severe.

Genome sequencing of a section of virus samples by a consortium of 10 laboratories across the country, called the Indian SARS-CoV-2 Consortium on Genomics (INSACOG), revealed the presence of two mutations, E484Q and L452R together, in at least 200 virus samples.

Mutations in the virus per se are not surprising but specific mutations that help the virus evolve to thwart vaccines or the immune system or are linked to a spike in cases or in disease severity are causes of concern.

While the two mutations have been individually identified in other variants of SARS-CoV-2 globally and have been associated with a reduction in vaccine efficacy, their combined effect and biological implications have not yet been understood.

In the days ahead, the INSACOG will submit details of this variant to a global repository called GISAID and, if it merits, classify it as a “variant of concern” (VOC).

So far, only three global VOCs have been identified: the U.K. variant (B.1.1.7), the South African (B.1.351) and the Brazilian (P.1) lineage.

After the new double variant has been submitted to GISAID, it will be categorised under a formal lineage, and will have its own name.