Thalassemia and sickle cell anaemia are caused due to a problem in globin molecule synthesis. Select the correct statement.

Thalassemia and sickle cell anaemia are caused due to a problem in globin molecule synthesis. Select the correct statement.

Option 1 : Thalassemia is due to less synthesis of globin molecules.
Option 2 : Both are due to a quantitative defect in globin chain synthesis.
Option 3 : Sickle cell anaemia is due to a quantitative problem of globin molecules.
Option 4 : Both are due to a qualitative defect in globin chain synthesis.