Which of the following statements is correct, with reference to enzymes?

Which of the following statements is correct, with reference to enzymes?

Option 1 : Apoenzyme = Holoenzyme + Coenzyme
Option 2 : Coenzyme = Apoenzyme + Holoenzyme
Option 3 : Holoenzyme = Apoenzyme + Coenzyme
Option 4 : Holoenzyme = Apoenzyme + Co-factor

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