Home ยป Which of the following hormone plays a major role in water reabsorption? Excretory System MCQs Which of the following hormone plays a major role in water reabsorption? January 24, 2022 4 Views Q. Which of the following hormone plays a major role in water reabsorption? A. Somatostatin B. Relaxasin C. Oxytocin D. Vasopressin Answer: Vasopressin