Bioinformatics Quiz | Bioinformatics Multiple Choice Questions and Answers

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Questions
1 Your lab partner is using BLAST, and his best E value is 3. This means that
A he’s found 3 proteins in the database that have the same sequence as his protein.
B the chance that these similarities arose due to chance is one in 10^3.
C there would be 3 matches that good in a database of this size by chance alone.
D the match in amino acid sequencs is perfect, except for the amino acids at 3 positions.

Answer: there would be 3 matches that good in a database of this size by chance alone.
2 If you enter a set of IUPAC codes into BLAST, you are probably trying to
A find out whether a certain protein has any role in human disease.
B search for the genes that are located on the same chromosome as a gene whose sequence you have.
C find which section of a piece of DNA is transcribed into mRNA.
D determine the identity of a protein.

Answer: determine the identity of a protein.
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3 What would be a likely explanation for the existence of pseudogenes?
A gene duplication
B gene duplication and mutation events
C mutation events
D unequal crossing over

Answer: gene duplication and mutation events
4 Two-dimensional gels are used to __________.
A separate DNA fragments
B separate RNA fragments
C separate different proteins
D observe a protein in two dimensions

Answer: separate different proteins
5 How are so many different antibodies produced from fewer than 300 major genes?
A gene duplication
B alternative splicing mechanisms
C the formation of polyproteins
D recombination, deletions, and random assortment of DNA segments

Answer: recombination, deletions, and random assortment of DNA segments
6 Gene duplication has been found to be one of the major reasons for genome expansion in eukaryotes. In general, what would be the selective advantage of gene duplication?
A If one gene copy is nonfunctional, a backup is available.
B Larger genomes are more resistant to spontaneous mutations.
C Duplicated genes will make more of the protein product.
D Gene duplication will lead to new species evolution.

Answer: If one gene copy is nonfunctional, a backup is available.
7 As the complexity of an organism increases, all of the following characteristics emerge except __________.
A the gene density decreases
B the number of introns increases
C the gene size increases
D an increase in the number of chromosomes

Answer: an increase in the number of chromosomes
8 CpG islands and codon bias are tools used in eukaryotic genomics to __________.
A identify open reading frames
B differentiate between eukaryotic and prokaryotic DNA sequences
C find regulatory sequences
D look for DNA-binding domains

Answer: identify open reading frames
9 Shotgun cloning differs from the clone-by-clone method in which of the following ways?
A The location of the clone being sequenced is known relative to other clones within the genomic library in shotgun cloning.
B Genetic markers are used to identify clones in shotgun cloning.
C Computer software assembles the clones in the clone-by-clone method.
D No genetic or physical maps of the genome are needed to begin shotgun cloning.

Answer: No genetic or physical maps of the genome are needed to begin shotgun cloning.
10 If you were using a proteomics approach to find the cause of a muscle disorder, which of the following techniques might you be using?
A creating a genomic library
B sequencing the gene responsible for the disorder
C developing physical maps from genomic clones
D determining which environmental factors influence the expression of your gene of interest annotating the gene sequence

Answer: determining which environmental factors influence the expression of your gene of interest annotating the gene sequence
11 Characterizing molecular component is
A Genomics
B Cheminformatics
C Proteomics
D Bioinformatics

Answer: Bioinformatics
12 Analysing or comparing entire genome of species
A Bioinformatics
B Genomics
C Proteomics
D Pharmacogenomics

Answer: Genomics
13 The identification of drugs through genomic study
A Genomics
B Cheminformatics
C Pharmagenomics
D Phrmacogenetics

Answer: Pharmagenomics
14 Human genome contains about
A 2 billion base pairs
B 3 billion base pairs
C 4 billion base pairs
D 5 billion base pairs

Answer: 3 billion base pairs
15 Deposition of cDNA into inert structure is
A DNA finingerprinting
B DNA polymerase
C DNA probes
D DNA microarrays

Answer: DNA microarrays
16 First molecular biology server Expasy in the year?
A 1991
B 1992
C 1993
D 1994

Answer: 1993
17 The tool for identification of motifs?
A COPIA
B patternhunter
C PROSPECT
D BLAST

Answer: COPIA
18 An example of Homology & similarity tool?
A PROSPECT
B EMBOSS
C RASMOL
D BLAST

Answer: BLAST
19 SWISSPROT protein sequence database began in
A 1985
B 1986
C 1987
D 1988

Answer: 1987
20 The first bioinformatics database was created by
A Richard Durbin
B Dayhoff
C Michael j.Dunn
D Pearson

Answer: Dayhoff

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