Chromosomal Aberrations MCQs | Chromosomal Aberrations Multiple Choice Questions and Answers

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Questions
1 Which of the following is not true about inversion?
A Two DNA strands with an inverted segment will not pair
B Inverted chromosomes are generally viable
C Inversion including centromere is known as paracenric
D Inversion can cause chromosome breakage

Answer: Two DNA strands with an inverted segment will not pair
2 Which of the following statement is incorrect
A Chromosome number is constant within different species in an ecosystem
B Chromosome number is constant within different somatic cells of an organism
C Chromosome number is constant within individuals in a species in an ecosystem
D All of these

Answer: Chromosome number is constant within different species in an ecosystem
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3 The size of chromosome is measured during
A Metaphase
B Anaphase
C Prophase
D All Of These

Answer: Metaphase
4 Euchromatin
A Is Partially Condensed
B Genetically Active Chromatin With Genes
C Stains Lightly
D All Of These

Answer: All Of These
5 Chromatin Has
A DNA
B DNA, RNA And Proteins
C DNA And Proteins
D None Of These

Answer: DNA, RNA And Proteins
6 A chromosome with a very short arm and a very long arm is termed as
A Sub-metacentric
B Telocentric
C Metacentric
D Acrocentric

Answer: Acrocentric
7 ______________ inversions reduce crossing over in ______________
A Pericentric, Heterozygous
B Pericentric homozygous
C Paracentric, Heterozygous
D Paracentric, homozygous

Answer: Pericentric, Heterozygous
8 Long pericentric inversions generally don’t act as cross over suppressors. Why?
A Cross over product in this is viable
B Two events of crossing over take place
C Long stretches of DNA recombination not recognized
D Mechanism is different for short and long inversions

Answer: Two events of crossing over take place
9 In drosophila male there is no cross over suppression due to pericentric inversion as___________
A They never recombine
B They have only one set of chromosome
C They don’t undergo meiosis
D They always have double cross over

Answer: They never recombine
10 How will you recognize a terminal deletion from breakage and loss at the terminal end?
A Terminal break will be sticky
B Deletion will be recognized by trans factors
C Indistinguishable
D Terminal break will lead to shorter chromosome than that due to chunk deletion

Answer: Terminal break will be sticky
11 You hybridize two cells one of which carries a deletion mutation on chromosome 1. What will you expect to observe?
A Buckling of chromatin of 2nd cell
B Buckling of chromatin of 1st cell
C No observable difference
D Twisting and loop formation between the two chromatins

Answer: Buckling of chromatin of 2nd cell
12 You generate a fluorescent probe against a gene that has been deleted. You expose the DNA to the probe and observe it under fluorescent microscope. What will you see?
A Nothing is seen under fluorescence microscope
B Most parts of the chromosome emits fluorescence
C Fluorescence will correspond to the gene of interest
D There will be a number of regions that emit fluorescence

Answer: Nothing is seen under fluorescence microscope
13 Deletion of a region led to over expression of a gene X. What do you conclude from this observation?
A Regulator of gene X is deleted
B No effect on gene X or its regulators
C Part of gene X is mutated
D Promoter of gene X is deleted

Answer: Regulator of gene X is deleted
14 Yellow colour of mouse is generated by _________ mutation.
A Deletion
B Translocation
C Duplication
D Inversion

Answer: Deletion
15 Which of the following is not true about the Notch gene in Drosophila?
A Notch is lethal in homozygous form
B Notch is recessive to Facet
C It causes a special indentation of the wing margin
D It is expressed in heterozygous form

Answer: Notch is recessive to Facet
16 Who coined the term ‘chromatin’ to describe the thread like material of the nucleus?
A Boveri
B W.Roux
C E. Strasburger
D W. Flemming

Answer: W. Flemming
17 The lowest level of chromosome organization is
A 30nm Fibre
B Solenoid
C Nucleosome
D None Of These

Answer: Nucleosome
18 Chromosome is thickest during
A Metaphase
B Interphase
C Prophase
D None Of These

Answer: Metaphase
19 Consider this sequence A—O—B —C—D—E—F, be a DNA sequence where O is the centromere. Which of the following will be a pericentric inversion?
A A—O—E—D—B—F
B D—B—O—A—E—F
C A—O—B—D—E—F
D B—O—A—D—E—F

Answer: A—O—E—D—B—F
20 What are the results of pericentric inversion with single crossing over?
A 2 dicentric and 2 acentric chromosomes
B 3 normal chromosome, one abnormal acentric chromosome
C Two normal, one dicentric and one acentric chromosome
D Four normal chromosomes with centriomere in different positions

Answer: Two normal, one dicentric and one acentric chromosome

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