Neurology Quiz | Neurology MCQs and Answers

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Questions
81 A 47-year-old man presents with memory impairment worsening over 9 months. He has jerking movements of his limbs and biphasic high-amplitude sharp waves on EEG. Which diagnosis is most likely?
A Alzheimer's disease
B Creutzfeld-Jakob disease
C Multi-infarct dementia
D Normal Pressure Hydrocephalus

Answer: Creutzfeld-Jakob disease
82 A 72-year-old woman has a five year history of worsening mental functioning with trouble remembering things. She has no problems with movement. She is noted on an MRI scan of the brain to have symmetrically increased size of the lateral ventricles along with cerebral cortical atrophy in a mainly frontal and parietal distribution. A lumbar puncture reveals a normal opening pressure, and analysis of the clear, colorless cerebrospinal fluid reveals a glucose and protein which are in normal ranges. Cell count on the CSF shows 3 WBCs (all lymphocytes) and 1 RBC. A fundoscopic examination is normal. Which of the following findings is most likely associated with her underlying disease process?
A Increased numbers of Lewy bodies
B Loss of Betz cells
C Loss of gamma aminobutyric acid (GABA)
D Presence of the e4 allele of apolipoprotein E

Answer: Presence of the e4 allele of apolipoprotein E
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83 A 60-year-old man was brought to casualty after a fall in his bathroom. Seen immediately by his family, he was already picking himself up from the floor and said he was not injured. His wife felt that he was transiently dazed. On examination, he was alert, and no abnormalities were noted. His past medical history included a history of hypertension for which he was taking bendrofluazide 2.5 mg daily. He was discharged without any further intervention. Two weeks later his wife brings the patient to see you because the dazed state has returned. Examination reveals a temperature of 36.7C, a pulse rate of 84 bpm regular, a blood pressure of 152/94 mm Hg. On questioning he is slightly slowed, being disoriented to time with some deficit in recent memory. The patient moves slowly, but power is normal. Neurologic examination shows slight hyperactivity of the tendon reflexes on the right with unclear plantar responses because of bilateral withdrawal. Which of the following would you request?
A 24-hour ambulatory electrocardiogram
B CSF analysis
C CT of the head
D Electromyography and nerve conduction testing

Answer: CT of the head
84 Which of the following forms of encephalitis is caused by a neuroimmunological response?
A Herpes simplex
B Measles
C HIV infection
D Enteral viruses

Answer: Measles
85 A 60-year-old woman presents with a 24 hours history of headache and vomiting. She has been on steroids for temporal arteritis for the last 3 years. Examination demonstrates pyrexia, neck stiffness, photophobia, dysarthria, nystagmus and ataxia. CSF shows neutrophilic pleocytosis, low glucose, elevated protein. What is the most likely diagnosis?
A Carcinomatosis meningitis
B Cryptococcal meningitis
C Listeria meningitis
D Meningococcal meningitis

Answer: Listeria meningitis
86 In which of the following is mental retardation an expected finding?
A Alkaptonuria
B Cystinuria
C Glycogen storage disease
D Maple syrup urine disease

Answer: Maple syrup urine disease
87 Which of the following is correct regarding Herpes simplex encephalitis?
A shows a peak incidence in the Autumn
B is associated with a polymorphonuclear pleocytosis in the CSF
C produces a diffuse, evenly distributed inflammation of cerebral tissues
D produces a typical EEG pattern with lateralised periodic discharges at 2 Hz

Answer: produces a typical EEG pattern with lateralised periodic discharges at 2 Hz
88 A 73-year-old man presents with an abrupt onset of double vision and left leg weakness. Examination shows weakness of abduction of the right eye, right-sided facial weakness affecting upper and lower parts of the face. He also has a left hemiparesis. Where is the lesion?
A left frontal lobe
B left lateral medulla
C right corpus striatum
D right pons

Answer: right pons
89 Which of the following statements regarding hiccup is true?
A Is caused by a tonic relaxation of the diaphragm.
B May be caused by local irritation to the vagus nerve.
C Can reliably be treated with theophylline.
D May be caused by a posterior fossa tumour.

Answer: May be caused by a posterior fossa tumour.
90 In considering the management of convulsions select the correct statement from the list below.
A If the fit lasts longer than 5 minutes, then PR diazepam should be given.
B Phenobarbitone is a useful therapy in school age children.
C Paraldehyde is best given intramuscularly.
D Hypoglycaemia should always be considered.

Answer: Hypoglycaemia should always be considered.
91 The action of noradrenaline released at sympathetic nerve endings is terminated by
A enzymatic decarboxylation
B enzymatic inactivation by catechol-O-methyl transferase
C re-uptake of noradrenaline by the axonal terminals
D oxidative deamination by monoamine oxidase

Answer: re-uptake of noradrenaline by the axonal terminals
92 A 65 year-old woman with 12 hour history of unsteady gait, sudden onset associated with vomiting and headache. Following this she had increasing drowsiness. What is the diagnosis?
A Acute subdural haemorrhage
B Cerebellar haemorrhage.
C Frontal subdural empyema
D Herpes simplex encephalitis.

Answer: Cerebellar haemorrhage.
93 A 18-year-old female presents with a 3 days history of progressive weakness and numbness of her legs, urinary retention and back pain 2 weeks following an upper respiratory infection. On examination there is spastic paraparesis, sensory level up to T5, extensor plantars. Examination of cranial nerves and upper limbs is normal. MRI of the spine is normal. The most likely diagnosis is:
A Multiple sclerosis
B Anterior spinal artery occlusion
C Post-infectious transverse myelitis
D Thoracic disc prolapse

Answer: Post-infectious transverse myelitis
94 A 40-year-old man with a long history of alcohol abuse is admitted with a subacute illness, comprising headache, fever, meningism and ataxia. MRI brain showed patchy high signal abnormality of the brain stem. CSF analysis showed polymphonuclear pleocytosis and low glucose. He had failed to improve after 3 days of intravenous cefotaxime treatment. The most likely diagnosis of the meningitis is:
A Mycobacterium tuberculosis
B Cryptococcus neoformans
C Nocardia asteroides
D Listeria monocytogenes

Answer: Listeria monocytogenes
95 A 27-year-old man presents with a two years history of intermittent tingling sensation involving his left side. It starts in his fingers and spreads in 10-20 seconds to affect the whole arm and leg on the same side. The attacks only last for one minute. The most likely diagnosis is:
A Migraine with aura
B Transient ischaemic attacks
C Somatosensory seizures
D Hyperventilation

Answer: Somatosensory seizures
96 A 43-year-old woman develops a progressive, ascending motor weakness over several days. She is hospitalized and requires intubation with mechanical ventilation. She is afebrile. A lumbar puncture is performed with normal opening pressure and yields clear, colorless CSF with normal glucose, increased protein, and cell count of 5/microliter, all lymphocytes. She gradually recovers over the next month. Which of the following conditions most likely preceded the onset of her illness?
A Ketoacidosis
B Staphylococcus aureus septicemia
C Systemic lupus erythematosus
D Viral pneumonia

Answer: Viral pneumonia
97 A 19-year-old woman presents to the clinic having had 5 blackouts over the last year, all while she is standing up. She gets warnings of blurred vision, nausea, feeling hot. She had been witnessed twice to have jerking of all limbs while she is unconscious. The attacks last 30-60 seconds. She recovers quickly after the attacks. She has never bitten her tongue or sustained any injuries. Physical examination and an ECG are normal. Her grandmother and sister suffer from epilepsy. Which of the following investigations is the most appropriate?
A EEG
B 24 hour ECG recording
C CT brain
D Tilt table test

Answer: Tilt table test
98 A 36 year-old man has a 3 month history of pain in feet and lower legs. He was diagnosed as having diabetes at age 14 and treated with insulin. He is a cannabis smoker and drinks 30 units of alcohol per week. On examination he has impaired pain and temperature sensation in feet and lower legs, normal joint position and vibration sense. His reflexes are normal. What is the diagnosis?
A Alcoholic polyneuropathy.
B Chronic inflammatory demyelinating polyneuropathy (CIDP)
C Diabetic polyneuropathy.
D Syringomyelia.

Answer: Diabetic polyneuropathy.
99 A lesion of the parietal lobe causes:
A Bitemporal hemianopia
B Homonymous inferior quadrantanopia
C Perseveration
D Primitive reflexes

Answer: Homonymous inferior quadrantanopia
100 The following are recognized features of Pancoast's tumour except:
A ipsilateral Horner's syndrome
B wasting of the dorsal interossei
C pain in the arm radiating to the fourth and fifth fingers
D weakness of abduction at the shoulder

Answer: weakness of abduction at the shoulder
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