Free download in PDF Pharmacology Multiple Choice Questions and Answers for competitive exams. These short objective type questions with answers are very important for competitive exams. These short solved questions or quizzes are provided by Gkseries.
1
A 58-year-old man has a history of obesity, gastro-oesophageal reflux disease, low back pain and IHD. He presents with large, itchy wheals over the trunk and limbs and a sensation of tightness in the throat. Which one of the following drugs is the most likely to have triggered this skin eruption?
2
A 30-year-old man presents with a history of transient loss of consciousness and palpitations. His ECG shows ventricular tachycardia.
Which of the following treatments should be avoided?
3
A 67 year old man presents with sudden onset atrial fibrillation (ventricular rate of 150/minute). His serum creatinine concentration was 250 umol/L (70-110). What is the main factor that determines the choice of loading dose of digoxin in this patient?
5
A youth worker, aged 40, presents to Accident and Emergency with vomiting. On detailed questioning, he admits to having taken 36 paracetamol tablets 2 hours previously. He is vomiting profusely with a BP of 90/60. Which of the following measures would be most appropriate?
6
A 24 year old man presented twelve hours after an overdose of dihydrocodeine 1.2 g and paracetamol 30 g. He had pinpoint pupils, a Glasgow Coma Scale score of 14 and a blood pressure of 100/60 mmHg. Which one of the following is the most appropriate management?
A
500ml of 10% glucose intravenously over four hours.
7
An 85 year old woman presented with bilateral osteoarthritis of the knees. She had no history of previous gastrointestinal disease. Which of the following is the most appropriate initial treatment for her?
11
A 51-year-old female is referred by her GP over concerns about osteoporosis. She had a hysterectomy and oophorectomy because of uterine fibroids one year ago, after which she developed hot flushes that now have stopped. Her elderly mother recently fractured the neck of her femur and the patient is worried about the possibility that she too will fracture her hip later in life. She is otherwise well, is a non-smoker drinks about 5 units of alcohol weekly and has a healthy diet.
Examination reveals a fit thin female with a BMI of 18, her blood pressure is 122/88mmHg and breast examination is normal. Which of the following would you recommend for her?
12
There is presently no known effective treatment for a chronic disease. A new treatment is known to be effective in animal models and shows promise in short-term studies in patients. There is some theoretical concerns regarding possible hepato- and bone marrow toxicity although thus far, no toxicity have been observed in studies.
What is the most appropriate next step in the drug's development?
A
A case control study
B
No further studies should be done and drug development should be stopped
C
An open study
D
A randomised double blind placebo controlled study
13
A 70 year old male was receiving amiodarone 200 mg daily for intermittent atrial fibrillation. However, he was aware of tiredness and lethargy. He appeared clinically euthyroid with no palpable goitre. Investigations revealed:
Serum free T4 23pmol/L (9-26)
Serum total T3 0.8 nmol/L (0.9-2.8)
Serum TSH 8.2 mU/L (<5)
Which of the following statements would explain these results?
16
A 70-year-old male is referred by his GP for management of recently diagnosed congestive heart failure. The patient has a history of poorly controlled hypertension. Over the last three months he has been aware of deteriorating shortness of breath, fatigue, and orthopnea. Over the last month he had been commenced on Digoxin (62.5 micrograms daily), Frusemide (80 mg daily), and amiloride 10 mg. On examination he has a pulse of 96 bpm regular, a blood pressure of 132/88 mmHg. His JVP was not raised, he had some scattered bibasal crackles on auscultation with a displaced apex beat in the anterior axillary line, 6th intercostal space. Auscultation of the heart revealed no murmurs and he had peripheral oedema to the mid tibia. Investigations showed:
electrolytes normal serum urea concentration 17 mmol/l (NR 2-8 mmol/l) creatinine 175 micromol/l (NR 55-110) Serum digoxin 0.7 ng/mL {therapeutic: 1.0-2.0}
One month previously his urea had been 11 mmol/l and creatinine 110 micromol/l. An ECG reveals left ventricular hypertrophy and Chest X-ray shows cardiomegaly and calcified aorta.
What is the most appropriate next step in management?
19
A 30 year old male presented with a paranoid psychosis accompanied by visual hallucinations which resolved over the next three days. Which one of the following is the most likely diagnosis?
