Nucleic Acid Objective Type Questions and Answers| Nucleic Acid Quiz

Questions

21 Which component is found in both guanosine and uridine?

A Both contain an aldohexose

B Both contain three hydroxyl groups

C Both contain a 1’,9 - bond

D Both contain a pyranose

View Answer

Answer: Both contain three hydroxyl groups

22 Which property is shared by both CTP and dTDP?

A Both contain the same sugar

B Both contain the same charge at cellular pH

C Both contain a planar six-membered ring

D Both contain phosphodiester bonds

View Answer

Answer: Both contain a planar six-membered ring

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23 Which is a general property of both nucleosides and nucleotides?

A Both contain a pentose in the form of a furanose

B Both contain at least one 5’-phosphate group

C Both contain a nitrogenous base that forms covalent H-bonds

D Both contain a hemiacetal or hemiketal bond

View Answer

Answer: Both contain a pentose in the form of a furanose

24 Which characteristic does this double-stranded molecule have when it forms a B- DNA structure?

A The two strands will have parallel orientation and identical sequences

B The helix will be right-handed with 12 base-pairs per turn

C Every base-pair will contain one purine and one pyrimidine

D There are both covalent and non-covalent bonds between the two chains

View Answer

Answer: Every base-pair will contain one purine and one pyrimidine

25 Which of the following double-stranded DNA molecules would denature at a lower temperature than the 40 base-pair double-stranded molecule described above?

A a 40 base-pair molecule in which 25% of the bases are adenines

B a 30 base-pair molecule in which 40% of the bases are guanines

C a 20 base-pair molecule in which 10% of the bases are thymines

D a 10 base-pair molecule in which 20 % of the bases are cytosines

View Answer

Answer: a 10 base-pair molecule in which 20 % of the bases are cytosines

26 Which characteristic will this double-stranded DNA molecule share with a double-stranded RNA molecule of the same size?

A Both will have secondary structure

B Both will contain inverted repeats

C Both will be degraded by base

D Both will contain four types of base-pairs

View Answer

Answer: Both will have secondary structure

27 Which will be a characteristic of this one single strand?

A The single-stranded chain will contain both ribose and deoxyribose

B The single-stranded chain will contain both purines and pyrimidines

C The single-stranded chain will contain one 5’-end and one 3’-end

D The single-stranded chain will contain multiple phosphodiester bonds each linking a 2’-carbon and a 5’-carbon

View Answer

Answer: The single-stranded chain will contain one 5’-end and one 3’-end

28 Which of the following are not the components of RNA?

A Thymine

B Adenine

C Guanine

D Cytosine

View Answer

Answer: Thymine

29 What is the composition of nucleotide?

A a sugar + a phosphate

B a base + a sugar

C a base + a phosphate

D a base + a sugar + phosphate

View Answer

Answer: a base + a sugar + phosphate

30 Which of the following is true about phosphodiester linkage?

A 5’-phosphate group of one nucleotide unit is joined to the 3’-hydroxyl group of the next nucleotide

B 3’-phosphate group of one nucleotide unit is joined to the 5’-hydroxyl group of the next nucleotide

C 5’-phosphate group of one nucleotide unit is joined to the 5’-hydroxyl group of the next nucleotide

D 3’-phosphate group of one nucleotide unit is joined to the 3’-hydroxyl group of the next nucleotide

View Answer

Answer: 5’-phosphate group of one nucleotide unit is joined to the 3’-hydroxyl group of the next nucleotide

31 Which of the following is false about purine and pyrimidine bases?

A They are hydrophobic and relatively insoluble in water at the near-neutral pH of the cell

B At acidic or alkaline pH the bases become charged and their solubility in water increases

C Purines have two rings in their structure, but pyrimidine bases have only one ring

D At acidic or alkaline pH the bases become charged and their solubility in water decreases

View Answer

Answer: At acidic or alkaline pH the bases become charged and their solubility in water decreases

32 Building blocks of nucleic acids are

A Nucleotides

B Nucleosides

C Amino acids

D Histones

View Answer

Answer: Nucleotides

33 Which of the following leads to disruption of nucleosomal structure?

A Acetylation

B Carboxylation

C Phosphorylation

D Methylation

View Answer

Answer: Methylation

34 Which of the following statements is not true about RNA?

A Does not have a double stranded structure

B Thymine is present

C Does not obey Chargaff’s rule

D The sugar contained in RNA is a ribose

View Answer

Answer: Thymine is present

35 Which component is found in both adenosine and deoxycytidine?

A Both contain a pyranose

B Both contain a 1,1’-N-glycosidic bond

C Both contain a pyrimidine

D Both contain a 3’-OH group

View Answer

Answer: Both contain a 3’-OH group

36 Which property is shared by both GDP and AMP?

A Both contain the same charge at neutral pH

B Both contain the same number of phosphate groups

C Both contain the same purine

D Both contain the same furanose

View Answer

Answer: Both contain the same furanose

37 Which characteristic is shared by purines and pyrimidines?

A Both contain two heterocyclic rings with aromatic character

B Both can form multiple non-covalent hydrogen bonds

C Both exist in planar configurations with a hemiacetal linkage

D Both exist as neutral zwitterions under cellular conditions

View Answer

Answer: Both can form multiple non-covalent hydrogen bonds

38 Which characteristic is shared by both adenine and cytosine?

A Both contain one methyl group

B Both are anomeric

C Both contain one keto group

D Both are heterocyclic

View Answer

Answer: Both are heterocyclic

39 Which characteristic is found in both purines and pyrimidines?

A They both have aromatic rings that undergo substantial tautomerization at neutral pH

B They both are weak bases that can be positively charged at neutral pH

C They both have multiple pKa values that result in zwitterion forms

D They both can form stable N-glycosidic bonds with β D-ribofuranose

View Answer

Answer: They both can form stable N-glycosidic bonds with β D-ribofuranose

40 Which force can stabilize a DNA double-helix?

A Hydrophobic bases are found in the interior of the helix where each base- pair is stabilized by the same number of hydrogen bonds

B Hydrophilic sugar-phosphate groups are found on the exterior of the helix where they can interact with water

C Non-covalent N-glycosidic bonds can form between nitrogenous bases in opposite strands in the helix

D Covalent base-stacking interactions can occur between adjacent bases within the same strand in the helix

View Answer

Answer: Hydrophilic sugar-phosphate groups are found on the exterior of the helix where they can interact with water

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