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Molecular Basis of Inheritance MCQs | GK Questions with Answers on Molecular Basis of Inheritance

(1) Which enzyme is used to remove the primer from the Okazaki fragment?
[A] Endonuclease
[B] RNase H
[C] 5’ exonuclease
[D] Polymerase
Answer: Polymerase
(2) Who of the following was not one of the scientists explaining the replicon model?
[A] Francois Jacob
[B] Sydney Brenner
[C] Jacques Cuzin
[D] Arthur Kornberg
Answer: Arthur Kornberg
(3) The replicon model was first explained in the year ____________
[A] 1950
[B] 1957
[C] 1963
[D] 1968
Answer: 1963
(4) The eukaryotic chromosome has a single replicon.
[A] True
[B] False
Answer: False
(5) The replicon model comprises of an initiator and _______________
[A] Replicator
[B] Origin of replication
[C] Dna A protein
[D] AT rich DNA
Answer: Replicator
(6) Replicator is the synonym for origin of replication.
[A] True
[B] False
Answer: Muton
(7) The initiator protein binds to a segment ____________ of the replicator sequence.
[A] Upstream
[B] Downstream
[C] At the end
[D] Within
Answer: Within
(8) Binding of the Dna A protein to the DNA is energy dependent.
[A] True
[B] False
Answer: True
(9) Assembly of how many proteins make up the origin replication complex (ORC) in eukaryotes?
[A] 2
[B] 4
[C] 6
[D] 8
Answer: 6
(10) Which of the following proteins is not recruited by Dna A protein?
[A] Dna A protein
[B] Helicase
[C] Dna C protein
[D] SSB protein
Answer: SSB protein
(11) Replication of chromosome occurs during the ____________ phase.
[A] G1
[B] S
[C] G2
[D] Division
Answer: S
(12) It is important to replicate the DNA correctly and only once.
[A] True
[B] False
Answer: True
(13) Selection of replicator occurs in ___________ phase.
[A] G1
[B] S
[C] G2
[D] Division
Answer: G1
(14) Activation of the origin of replication occurs in ____________ phase.
[A] G1
[B] S
[C] G2
[D] Division
Answer: S
(15) The replicator selection is mediated by the formation of pre-replicative complex. It comprises of _________________
[A] ORC and the initiator protein
[B] ORC and helicase
[C] A helicase loader and a helicase
[D] An ORC, two helicase loaders and a helicase
Answer: An ORC, two helicase loaders and a helicase
(16) The pre – RCs are auto-activated as soon as the cell enters the S – phase.
[A] True
[B] False
Answer: False
(17) Which of the following is wrong about the cyclin dependent kinases?
[A] Phosphorylates enzymes
[B] Activates pre – RCs
[C] Promotes formation of new pre – RCs
[D] Activates in the S – phase
Answer: Promotes formation of new pre – RCs
(18) Active cyclin dependent kinase is absent in ____________ phase.
[A] G1
[B] S
[C] G2
[D] Division
Answer: G1
(19) A sample of DNA contains 20% of adenine. What is the quantity of guanine present?
[A] 30
[B] 20
[C] 15
[D] 25
Answer: 20
(20) Who proposed the concept of reverse transcription?
[A] Crick & Temmin
[B] Temmin & Baltimore
[C] Watson & Chargaff
[D] Chargaff
Answer: Temmin & Baltimore

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