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Free download in PDF Molecular Basis of Inheritance Very Short Questions and Answers for competitive exams. These short objective type questions with answers are very important for Board exams as well as competitive exams like NEET, AIIMS, JIPMER etc. These short solved questions or quizzes are provided by Gkseries./p>
(1)
Which of the following does not affect DNA replication?
[A]
Antiparallel nature of DNA
[B]
End specificity of polymerase
[C]
SSB protein
[D]
Helicase
(2)
Who was the first person to analyse the process of replication and on which organism?
[A]
Arthur Kornberg: E. coli
[B]
John Cairns: E. coli
[C]
Arthur Kornberg: Bacillus subtilis
[D]
John Cairns: Bacillus subtilis
Answer: John Cairns: E. coli
(3)
In the case of a circular DNA synthesis how many replication forks are observed?
(4)
Primer synthesis short stretches of DNA for replication.
(5)
Which of the following is not used for degrading RNA from RNA:DNA hybrid in replication?
[A]
RNase A
[B]
RNase H
[C]
Polymerase I
[D]
Exonuclease
(6)
The gaps formed by the hydrolyzing the RNA from RNA:DNA hybrid is filled by DNA polymerase I and the nicks are ligated by T4 ligase
(7)
Which of the following is correctly matched with its subsequent role?
[A]
Topoisomerase II- can remove both positive and negative supercoil in the DNA duplex
[B]
Polymerase I- larger fragment responsible for exonuclease activity
[C]
DnaA protein- responsible for “melting” of the DNA double helix during replication
[D]
DnaB protein- attaches to the newly unwounded single strand of DNA to prevent folding of the strand
Answer: DnaA protein- responsible for “melting” of the DNA double helix during replication
(8)
Which of the following types of DNA polymerase has 3’→5’ exonuclease activity?
[A]
DNA polymerase I
[B]
DNA polymerase II
[C]
DNA polymerase III
[D]
DNA polymerase IV
(9)
Choose the odd one out with respect to DNA polymerase III.
[A]
dna E
[B]
dna N
[C]
dna Q
[D]
dna B
(10)
DNA polymerase II can polymerase upto ______________ nucleotides per minute at 37˚C.
[A]
50
[B]
500
[C]
5000
[D]
50000
(11)
All mutation in polymerases is lethal except the mutation of polymerase III.
(12)
Polymerase I has the highest affinity for dNTPs.
(13)
Polymerase I has two fragments. The residue of larger fragment consists from ____________ residues.
[A]
1 – 234
[B]
234 – 658
[C]
324 – 928
[D]
234 – 928
(14)
Which of the following is false about klenow fragment?
[A]
Polymerization activity
[B]
3’→5’ exonuclease activity
[C]
5’→3’ exonuclease activity
[D]
324 – 928 residue of polymerase I
Answer: 3’→5’ exonuclease activity
(15)
DNA polymerase III has ___________ subunits.
a) 4
b)
c)
d)
View Answer
Answer: d
(16)
Which of the following types of DNA polymerase does not take part in DNA repair?
[A]
DNA polymerase I
[B]
DNA polymerase II
[C]
DNA polymerase III
[D]
DNA polymerase IV
Answer: DNA polymerase III
(17)
How many active sites are present in the DNA polymerase to catalyze the addition of the four dNTPs?
(18)
How does the polymerase recognize the correct dNTP for an addition?
[A]
Structure of dNTP
[B]
Molecular weight of dNTP
[C]
Purine and pyrimidine orientation
[D]
Ability of hydrogen bond formation
Answer: Ability of hydrogen bond formation
(19)
DNA polymerase can distinguish between dNTPs and rNTPS due to ___________
[A]
Structural differentiation
[B]
Steric exclusion
[C]
Steric hindrance
[D]
Enzyme substrate mismatch
(20)
When we compare the structure of DNA polymerase to the structure of a body part, it resembles to _________________
[A]
Right hand
[B]
Left hand
[C]
Right foot
[D]
Left foot
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