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Molecular Basis of Inheritance MCQs | Molecular Basis of Inheritance Very Short Questions and Answers

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(1) With respect to the palm domain of the DNA polymerase which of the following is not its property?
[A] Contains primary elements of the catalytic site
[B] Binds to 2 divalent ions
[C] Composed of α helix
[D] Brings about the environmental changes around 3’-OH of dNTP
Answer: Composed of α helix
(2) The two divalent metal ions of the active sites of DNA polymerase are major catalytic elements that bring about changes required for the joining of the dNTPs.
[A] True
[B] False
Answer: True
(3) Mismatched DNA does not affect the rate of activity of DNA polymerase.
[A] True
[B] False
Answer: False
(4) Which is the rate limiting step of DNA replication?
[A] Formation of the RNA primer
[B] Binding of primer to the DNA template
[C] Binding of DNA polymerase to the primer:template junction
[D] Binding of the first dNTP to the primer
Answer: Binding of DNA polymerase to the primer:template junction
(5) Which of the following is not true about nucleotides?
[A] Monomeric units
[B] Ubiquitous substances
[C] Energy rich molecules
[D] Non enzymatic molecules
Answer: Non enzymatic molecules
(6) The nitrogenous base is covalently linked to the _________ carbon of the pentose sugar.
[A] C1
[B] C2
[C] C3
[D] C4
Answer: C1
(7) In which carbon do the deoxyribonucleotides lack an –OH molecule?
[A] C1
[B] C2
[C] C3
[D] C4
Answer: C2
(8) Which of the following is not a part of a nucleotide?
[A] Ester linkage
[B] Phosphate group
[C] Base
[D] Hydrogen bond
Answer: Hydrogen bond
(9) Which of the following is not a part of a nucleoside?
[A] Deoxyribose sugar
[B] Glycosidic linkage
[C] Phosphate
[D] Base
Answer: Phosphate
(10) The linkage between the sugar and the base is a covalent linkage.
[A] True
[B] False
Answer: True
(11) Which of the following is not a nucleotide?
[A] AMP
[B] TMP
[C] GMP
[D] CMP
Answer: TMP
(12) Purines and pyrimidines form glycosidic linkage with the purines and pyrimidines at the N6 position.
[A] True
[B] False
Answer: False
(13) With respect to DNA polymerase holoenzyme pick the odd one out.
[A] 2 copies of DNA polymerase III
[B] 5 protein γ complex
[C] Presence of ATP
[D] Presence of DNA
Answer: Presence of DNA
(14) A complete DNA polymerase III holoenzyme contains ____________ subunits.
[A] 2
[B] 4
[C] 6
[D] 8
Answer: 6
(15) How many polymerases are present in a replication fork?
[A] 2
[B] 3
[C] 4
[D] 5
Answer: 3
(16) With respect to eukaryotic replication which of the following enzyme is not correctly paired with its function?
[A] Primase – initiation of new strand synthesis
[B] RF-C – recruitment, maintenance and coordination of DNA polymerases
[C] DNA polymerase ε – elongation of DNA strand
[D] τ protein – binds to DNA polymerase
Answer: RF-C – recruitment, maintenance and coordination of DNA polymerases
(17) The formation of the phosphodiester bond is an example of _________ reaction.
[A] SN1
[B] SN2
[C] E1
[D] E2
Answer: SN2
(18) DNA synthesis is known as a coupled process.
[A] True
[B] False
Answer: True
(19) DNA helicase travels along _________
[A] Leading strand template in 3’→5’ direction
[B] Leading strand template in 5’→3’ direction
[C] Lagging strand template in 3’→5’ direction
[D] Lagging strand template in 5’→3’ direction
Answer: Lagging strand template in 5’→3’ direction
(20) DNA polymerase III holoenzyme does not need to interact with the helicase during replication.
[A] True
[B] False
Answer: False

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