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Molecular Basis of Inheritance MCQs | Molecular Basis of Inheritance Very Short Questions and Answers

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Questions
1 With respect to the palm domain of the DNA polymerase which of the following is not its property?
A Contains primary elements of the catalytic site
B Binds to 2 divalent ions
C Composed of α helix
D Brings about the environmental changes around 3’-OH of dNTP

Answer:Composed of α helix
2 The two divalent metal ions of the active sites of DNA polymerase are major catalytic elements that bring about changes required for the joining of the dNTPs.
A True
B False

Answer:True
3 Mismatched DNA does not affect the rate of activity of DNA polymerase.
A True
B False

Answer: False
4 Which is the rate limiting step of DNA replication?
A Formation of the RNA primer
B Binding of primer to the DNA template
C Binding of DNA polymerase to the primer:template junction
D Binding of the first dNTP to the primer

Answer:Binding of DNA polymerase to the primer:template junction
5 Which of the following is not true about nucleotides?
A Monomeric units
B Ubiquitous substances
C Energy rich molecules
D Non enzymatic molecules

Answer: Non enzymatic molecules
6 The nitrogenous base is covalently linked to the _________ carbon of the pentose sugar.
A C1
B C2
C C3
D C4

Answer:C1
7 In which carbon do the deoxyribonucleotides lack an –OH molecule?
A C1
B C2
C C3
D C4

Answer: C2
8 Which of the following is not a part of a nucleotide?
A Ester linkage
B Phosphate group
C Base
D Hydrogen bond

Answer:Hydrogen bond
9 Which of the following is not a part of a nucleoside?
A Deoxyribose sugar
B Glycosidic linkage
C Phosphate
D Base

Answer:Phosphate
10 The linkage between the sugar and the base is a covalent linkage.
A True
B False

Answer:True
11 Which of the following is not a nucleotide?
A AMP
B TMP
C GMP
D CMP

Answer:TMP
12 Purines and pyrimidines form glycosidic linkage with the purines and pyrimidines at the N6 position.
A True
B False

Answer: False
13 With respect to DNA polymerase holoenzyme pick the odd one out.
A 2 copies of DNA polymerase III
B 5 protein γ complex
C Presence of ATP
D Presence of DNA

Answer: Presence of DNA
14 A complete DNA polymerase III holoenzyme contains ____________ subunits.
A 2
B 4
C 6
D 8

Answer: 6
15 How many polymerases are present in a replication fork?
A 2
B 3
C 4
D 5

Answer:3
16 With respect to eukaryotic replication which of the following enzyme is not correctly paired with its function?
A Primase – initiation of new strand synthesis
B RF-C – recruitment, maintenance and coordination of DNA polymerases
C DNA polymerase ε – elongation of DNA strand
D τ protein – binds to DNA polymerase

Answer:RF-C – recruitment, maintenance and coordination of DNA polymerases
17 The formation of the phosphodiester bond is an example of _________ reaction.
A SN1
B SN2
C E1
D E2

Answer:SN2
18 DNA synthesis is known as a coupled process.
A True
B False

Answer:True
19 DNA helicase travels along _________
A Leading strand template in 3’→5’ direction
B Leading strand template in 5’→3’ direction
C Lagging strand template in 3’→5’ direction
D Lagging strand template in 5’→3’ direction

Answer: Lagging strand template in 5’→3’ direction
20 DNA polymerase III holoenzyme does not need to interact with the helicase during replication.
A True
B False

Answer: False

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