Molecular Basis of Inheritance MCQs | Short Questions with Answers on Molecular Basis of Inheritance

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Questions
1 What marks the difference between the solenoid and the zig-zag models of 30 nm fibres?
A Linker histone molecule
B Linker DNA
C Nucleosome structure
D 10 nm fibre

Answer:Linker DNA
2 The histone tails stabilize the 30 nm fibre by interacting with adjacent nucleosomes.
A True
B False

Answer: True
3 Which of the following is not a characteristic of the nuclear scaffold?
A Associated with loops of 40 – 90 kb
B Topoisomerase I
C SMC protein
D Proteinacious in nature

Answer: Topoisomerase I
4 Which histone molecule produces novel binding sites for protein components of the kinetochore?
A CENP – A
B H2A
C H3
D H4

Answer:CENP – A
5 With respect to remodeling complex of nucleosome, which of the following is not true?
A Does not require ATP
B Favors sliding of histone
C Favors transfer of histone
D Favors remodeling of histone

Answer:Does not require ATP
6 The positioning of nucleosome is beneficial.
A True
B False

Answer: True
7 Which of the following facilitates nucleosome positioning?
A Nucleosome remodeling complex
B Topoisomerase II
C SMC protein
D DNA – binding protein

Answer: DNA – binding protein
8 Which of the following regions promote histone – DNA association?
A A, T
B A, G
C G, C
D C, T

Answer:A, T
9 With respect to end terminal modification of the histone tail which of the following options is true?
A Lysine – phosphate modification
B Serine – methylation
C Acetylation – transcriptionally active
D Modifications – involvement in gene expression

Answer:Modifications – involvement in gene expression
10 Which of the following is a function of a modified histone tail?
A Association with adjacent nucleosome
B Interaction with DNA backbone
C Interaction with chromodomains
D Formation of 40-fold DNA structure

Answer: Interaction with chromodomains
11 Bromodomains of proteins are associated with phosphorylated histone tails.
A True
B False

Answer: False
12 Which of the following enzymes of transcription commonly contains a bromodomain?
A TFIID
B CDK
C Pre – RC
D DNA polymerase

Answer: TFIID
13 Which of the following enzymes is not correctly paired with its function?
A Acetyl transferase – adds acetyl group to lysine
B Methyl transferase – adds methyl group to serine
C Topoisomerase – associated with nuclear scaffold
D Deacetylases – removes acetyl groups from serine

Answer:Methyl transferase – adds methyl group to serine
14 Which of the following is not promoted by histone tail modification?
A Formation of repressive structures
B Gene expression
C Nucleosome remodeling
D Nucleosome sliding

Answer: Nucleosome sliding
15 Which of the following is not a part of a gene?
A Ori
B Promoter
C Operon
D Terminator

Answer:Ori
16 What is the correct order for increasing gene density?
A Bacteria, Virus, Fruit fly, Human
B Fruit fly, Bacteria, Virus, Human
C Human, Fruit fly, Bacteria, Virus
D Virus, Bacteria, Fruit fly, Human

Answer:Human, Fruit fly, Bacteria, Virus
17 Which of these factors contribute to a decrease in gene density?
A Operon
B Intergenic sequence
C Exon sequence
D All of these

Answer:Intergenic sequence
18 What do you think is the requirement of Intergenic DNA in higher organisms?
A Just genetic load
B To avoid viable mutations
C Helps in regulation of transcription
D Helps in genome organization

Answer:To avoid viable mutations
19 Which of the following is not a character of unique Intergenic DNA?
A Mutant genes
B Pseudogenes
C Palindromes
D Nonfunctional gene fragments

Answer: Palindromes
20 Which of the following is responsible for the formation of Pseudogenes?
A Polymerase
B Reverse transcriptase
C Klenow fragment
D Wrong primer

Answer: Reverse transcriptase

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