Molecular Basis of Inheritance MCQs | Objective Type Questions with Answers on Molecular Basis of Inheritance

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Questions
1 Amino acids prior to their incorporation into polypeptide must be attached to a special adaptor molecule. Who proved this and when?
A Francis H. Crick in 1955
B Paul C. Zamecnic and Maholon B. Hoagland in 1957
C James Watson and Francis H. Crick in 1953
D Linus Pauling in 1950

Answer:Paul C. Zamecnic and Maholon B. Hoagland in 1957
2 With respect to polymerization of amino acids which of the following statements is wrong?
A The polymerization machinery consists of fifty proteins and two RNA molecules
B Overall molecular mass 2.5 megadalton
C Occurs at a slow pace of only 2 – 20 amino acids per second
D In eukaryotes the process occurs in the cytoplasm

Answer:The polymerization machinery consists of fifty proteins and two RNA molecules
3 Ribosome begins its translation at the 3’ end of the mRNA in prokaryotes.
A True
B False

Answer:False
4 Check which one of the following mechanisms is wrongly paired with its location of occurrence?
A Transcription – nucleus
B Post transcriptional mechanism – ER
C Translation – cytoplasm
D Post translational mechanism – ER

Answer:Post transcriptional mechanism – ER
5 With respect to the subunits of ribosome which of the following is wrongly paired?
A Ribosome = rRNA + protein
B Large subunit = decoding center
C Small subunit = decoding center
D Subunit sedimentation unit = Svedberg

Answer: Large subunit = decoding center
6 An mRNA bearing multiple ribosomes is known as______________
A Small subunit-mRNA-initiator tRNA complex
B mRNA ribosome complex
C Polyamine-ribosome complex
D Polysome

Answer:Polysome
7 What is the actual substrate for each round of amino acid addition?
A Ribosome
B Amino acid
C mRNA
D tRNA

Answer:tRNA
8 The reaction to form a new peptide bond is known as the peptidyl transferase reaction.
A True
B False

Answer:True
9 Where does ribosome gets the energy for the formation of peptide bond?
A Breaking of the keto bond
B Breaking of acyl bond
C Simultaneous hydrolysis of ATP
D Energy released during peptidyl transferase reaction

Answer: Breaking of acyl bond
10 With respect to the mRNA – ribosome complex for translation mechanism which of the following pair is wrong?
A Small subunit – decoding center
B A site – aminoacylated tRNA binding site
C P site – peptidyl tRNA binding site
D E site – polypeptide exit site

Answer:E site – polypeptide exit site
11 Only a single stranded RNA can pass through the ribosome for decoding.
A True
B False

Answer: True
12 How many channels are present in the ribosome?
A 2
B 3
C 4
D 5

Answer: 3
13 Which of the following is a character of ORF?
A Contiguous
B 3 – nucleotide codons
C Intron
D Non – overlapping

Answer: Intron
14 With respect to the open reading frame (ORF) which of the following is wrong?
A Starts at 5’ end
B ‘AUG’ is the only start codon for both prokaryotes and eukaryotes
C The start codon defines the reading frame for all the subsequent codons
D The stop codon is distinct from the ends of the mRNA

Answer: ‘AUG’ is the only start codon for both prokaryotes and eukaryotes
15 With respect to polycistronic mRNAs which of the following is wrong?
A Multiple ORFs
B Found in eukaryotes
C Encodes proteins with related functions
D Multiple polypeptide chain

Answer:Found in eukaryotes
16 What was the name of the ribosome binding site?
A ORF
B RBS
C A site
D Shine – Dalgarno sequence

Answer:A site
17 Which part of the ribosome identifies the Shine – Dalgarno sequence?
A Protein
B 16S rRNA
C 23S rRNA
D 5S rRNA

Answer:16S rRNA
18 Eukaryotic mRNAs recruit ribosomes using the Shine – Dalgarno sequence.
A True
B False

Answer: False
19 Eukaryotic mRNA is read in the 3’ to 5’ direction.
A True
B False

Answer: False
20 Which one of the following is known as the Kozak sequence?
A 5’…..CNNAUCG…..3’
B 5’…..GNNAUGG…..3’
C 5’…..TNNAUGG…..3’
D 5’…..GNNAUGC…..3’

Answer:5’…..GNNAUGG…..3’

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