Molecular Basis of Inheritance MCQs | Short Questions and Answers on Molecular Basis of Inheritance

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Questions
1 With respect to the composition of the ribosome which of the following is correct?
A Ribosome is composed of 60S and 30S subunit
B Eukaryotic ribosome small subunit contains only one 16S rRNA
C 60S subunit consists of 5S rRNA and 23S rRNA
D 60S and 40S makes up the 80S ribosome

Answer:60S and 40S makes up the 80S ribosome
2 Which element of the ribosome plays a key role in mRNA translation?
A rRNA of the large subunit
B Proteins of the large subunit
C rRNA of the small subunit
D Proteins of the small subunit

Answer: rRNA of the small subunit
3 The 3’ end of tRNA is __________
A 3’ CCA 5’
B 3’ ACC 5’
C 3’ CCG 5’
D 3’ GCC 5’

Answer:3’ ACC 5’
4 Thymine is present in tRNA.
A True
B False

Answer:True
5 With respect to tRNA which of the following is not its characteristic?
A Complimentary region
B Double helix molecule
C Highly conserved pattern of fold
D Variable loop

Answer: Double helix molecule
6 How many loops are present in the clover leaf model of tRNA?
A 2
B 3
C 4
D 5

Answer:4
7 In the beads on a string model, the bead is made up of __________
A 6 histone proteins
B 8 histone proteins
C 6 histone proteins and DNA
D 8 histone proteins and DNA

Answer:8 histone proteins
8 The unpacked stretches of DNA are the extra chromosomal load found in the eukaryotic genome.
A True
B False

Answer:False
9 How many types of histone molecules are found in nature?
A 3
B 4
C 5
D 6

Answer: 5
10 Nucleosome is made up of __________
A DNA, histone core protein
B DNA, histone core protein, linker H1
C RNA, histone core protein
D RNA, histone core protein, linker H1

Answer: DNA, histone core protein, linker H1
11 Histones have a high content of negatively charged amino acids.
A True
B False

Answer:False
12 With respect to assembly of every core histone which of the following is wrong?
A A conserved region
B Histone fold domain
C Disc shaped structure
D 2 α helices and an unstructured loop

Answer: 2 α helices and an unstructured loop
13 Which of the following histone pairs forms tetramers in solution?
A H1, H2A
B H2A, H2B
C H2B, H3
D H3, H4

Answer:H3, H4
14 With respect to the “tails” of the histone molecules which of the following is not true?
A N – terminal extension
B Lacks defined structure
C Required for the association of nucleosome
D Sites for extensive modifications

Answer:Required for the association of nucleosome
15 How many contacts are observed between the DNA and the histone core protein?
A 14
B 21
C 54
D 17

Answer: 14
16 Association of DNA and histone is mediated by _________
A Covalent bonding
B Hydrogen bonding
C Hydrophobic bonding
D Vander Waals interactions

Answer:Hydrogen bonding
17 Histone H1 binds two DNA helices.
A True
B False

Answer:True
18 The distinct zig-zag appearance of the chromatin fibre is due to ____________
A Nucleosome
B Histone H1
C Histone core
D Linker DNA

Answer: Histone H1
19 With respect to Histone H1 DNA packaging which of the following is false?
A H1 induce 10 nm fibre formation
B H1 binding gives nucleosome a defined angle
C H1 stabilizes higher order chromatin structures
D H1 binds to two DNA helices at once

Answer: H1 induce 10 nm fibre formation
20 With respect to the solenoid model of nucleosome, which of the following is true?
A Helical model
B 8 nucleosomes per turn
C Structure supported by X – ray diffraction
D Helical pitch of approximately 13 nm

Answer: Structure supported by X – ray diffraction

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